mathurāāsiyā — when he came to Mathurā; rāya — Subuddhi Rāya; prabhu-vārtāpāila — got information of the Lord’s itinerary; prabhura — of Lord Caitanya Mahāprabhu; lāga — contact; nāpāñā — not getting; mane — in the mind; baḍa — very great; duḥkha — unhappiness; haila — there was.
Translation:
After reaching Mathurā, Subuddhi Rāya received information of the Lord’s itinerary. He became very unhappy because he was not able to contact the Lord.