CC Madhya 25.203

mathurā āsiyā rāya prabhu-vārtā pāila
prabhura lāga nā pāñā mane baḍa duḥkha haila
Word for word: 
mathurā āsiyā — when he came to Mathurā; rāya — Subuddhi Rāya; prabhu-vārtā pāila — got information of the Lord’s itinerary; prabhura — of Lord Caitanya Mahāprabhu; lāga — contact; pāñā — not getting; mane — in the mind; baḍa — very great; duḥkha — unhappiness; haila — there was.
Translation: 
After reaching Mathurā, Subuddhi Rāya received information of the Lord’s itinerary. He became very unhappy because he was not able to contact the Lord.